Activate FOXO3 — The Gene That Helps You Age Well
Activate FOXO3 — The Gene That Helps
You Age Well
Written by: Clement Ng, Nutritionist
of HealthPro
Introduction
Geroprotectors,
compounds that act to slow down the aging process and delay the onset of
age-related diseases, have emerged as means to prolong healthspan in the aging
population
Central to
these geroprotectors is FOXO3, a geroprotective gene that has been consistently
associated with human longevity
Studies have
shown FOXO3 to play an essential role to slow down aging by being a significant
regulator of cellular stress resistance, DNA repair, and cell cycle
What are
FOXO genes?
FOXO genes,
or Forkhead Box O genes, are a group of genes that play a significant role in
regulating longevity-related functions including cellular homeostasis, stress
resistance
FOXO genes
encode transcription factors known as FOXO proteins that bind to specific
regions on DNA to turn specific genes on or off
Insights
of FOXO3
Research on
FOXO proteins, particularly FOXO3, has discovered its multifaceted role not
only in human longevity, but also in all-cause mortality
Longevity: FOXO3 are associated with extremely
long lives and are called ‘protective genes’ as they enhance protective
functions such as supporting antioxidant defence and stimulating cellular
repair
Cancer: FOXO3 is recognised as a tumour
suppressor as its inactivation can lead to uncontrolled cell proliferation and
poor survival rate among cancer patients
Cardiovascular
Disease: Alterations
of FOXO3 gene is associated with lower incidence of cardiovascular disease
Therefore,
FOXO3 represents the most potent gene to target in promoting healthy longevity
FOXO3-activating
nutraceuticals
As FOXO3
becomes increasingly recognised as a longevity gene, it is important to
identify the compounds that contribute to its activation to promote healthy longevity
While
pharmaceuticals like metformin and vorinostat are found to activate FOXO3,
nutraceuticals are also proven to be potent FOXO3 activators and should be
prioritised in daily life.
Below are
some of the nutraceuticals proven to extend lifespan in a FOXO3-dependant
manner
· AMPK (AMP-activated Protein Kinase)
· Phosphatidylcholine
· NAD (Nicotinamide Adenine
Dinucleotide)
· PQQ (Pyrroloquinoline Quinone)
· Resveratrol
· Curcumin
· Quercetin
· EGCG (Epigallocatechin-3-Gallate)
· Astaxanthin
· Melatonin
· Fisetin
Factors Influencing
FOXO3
While FOXO3
works like a highly calibrated sensor that responds to different stimuli within
the microenvironment of a cell, it can be affected by lifestyle factors and
food choices
For instance,
food rich in omega-3 such as salmon and mackerel and sources of antioxidants including
berries, nuts, and leafy greens are also found to enhance FOXO3 activity. In
addition, dark chocolate and green tea which are high in polyphenols also
contribute to the activation of FOXO3
Hence, the
incorporation of a balanced diet consisting of these nutrient-packed foods is
significant in promoting longevity via the action of FOXO3
Application
As life
expectancy increases, the risk of suffering from age-related diseases also
increases in the absence of an effective preventative approach
Although a healthy
diet is critical in enhancing the body’s protective mechanism by sustaining
FOXO3 activity and support cellular stress resistance
Thus,
supplementation of the FOXO3-activating nutraceuticals becomes a practical way
to support longevity at the cellular level.
As such, Life
Extension NAD+ Cell Regenerator™ and Resveratrol Elite™ becomes a friendly
option as it provides 4 nutraceuticals including NAD, Resveratrol, Quercetin,
and Fisetin in one product.
The formula
activates the sirtuin longevity genes, maintain telomere length for continuous
repair and hasten removal of senescent cells which would otherwise cause
inflammation.
The
ingredients are also FOXO3-activating compounds that work synergistically in
activating FOXO3 to enhance cellular resilience and promote healthy aging.
Besides, the
product also supports energy metabolism, cardiovascular health, and overall
vitality, making it a convenient choice to maintain longevity from within.
References
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