Strong MIYARISAN® Probiotics, 90 tablets

Strong MIYARISAN® helps maintain gastrointestinal balance for

immune, digestive and bowel movement health.

Accordingly, it has established a role in:

·         Managing Irritable Bowel Syndrome (IBS)

·         Preventing antibiotic-associated diarrhoea

·         Ameliorating GI effects of H pylori eradication therapy

·         Managing diarrhoea

·         Managing constipation

Rich Heritage of More Than 80 Years!

It provides the Clostridium butyricum Miyairi® 588 (CBM588®) strain which was first isolated by Dr Chikaji Miyairi in Japan’s Chiba Medical University in 1933.

Once commercial production began in 1940, it was quickly adopted for use in various Asian countries (Japan, Korea, and China) for managing diarrhoea and constipation for more than 80 years now.

The safety of the CBM588® strain of Clostridium butyricum is well established. It is naturally found in the human gut, and it does not carry any genes encoding any toxins and virulence factors associated with Clostridium or other intestinal pathogens.

It is granted GRAS (Generally Regarded as Safe) status for use in US and as a novel food ingredient in EU. ¹

Mode of Actions

CBM588® is resistant to stomach acid, heat, and antibiotics, allowing it to reach the intestines undenatured to proliferate.

During the process of proliferation, CBM588® produces butyric acid which brings about various beneficial effects:

1.    It increases the abundance of Bifidobacterium, Lactobacillus, and Lactococcus species to improve the gut microbiome balance.^2,5

2.    Short-chain fatty acids such as butyric acid produced by CBM588® is used as an energy source for the intestinal lining’s epithelial cells and contribute towards strengthening the gastrointestinal barrier.²

3.    It modulates inflammatory processes and the intestinal immune response, helping to maintain a stable intestinal environment.²

 Application: Manage Irritable Bowel Syndrome (IBS)

The gut immune system interacts with the gut microbiota and maintains intestinal homeostasis.

 Accumulating evidence supports the idea that imbalance in this complicated network between the immune system and the microbiota is involved in the pathogenesis of gut inflammatory diseases, including IBS. ⁸

Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response, thereby preventing damage to the host and maintaining normal tissue homeostasis.

CBM588® ability to induce IL-10-producing immunoregulatory macrophages is being studied for its potential as an immunomodulatory probiotic for both maintenance and induction of remission in IBS, by targeting intestinal macrophages. ^9,10