Life Extension B12 Elite, 60 lozenges

Life Extension Life Extension B12 Elite, 60 lozenges QR Code
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Vitamin B12 is essential for proper biological processes. Serum levels of vitamin B12 can decline over time, and because it’s found primarily in animal products, vegetarian diets may not provide sufficient B12. Our B12 Elite gives you 500 mcg each of adenosylcobalamin and methylcobalamin: two neurologically active forms of B12.

B12 Elite combines two forms of this vitamin—both of which are essential for proper bodily and neurological function.

B12 Elite Benefits:

  • Novel formula delivers two forms of bioactive B12
  • Helps protect delicate brain cells
  • Promotes healthy dopamine levels
  • Encourages healthy B12 serum levels
  • Promotes overall brain health

Vitamin B12 is good for you. But many people don’t get sufficient B12 from their diets alone. Reasons range from age-related insufficiency to dietary intake: B12 comes primarily from animal sources, so those following a vegetarian diet may not get enough.

Our new B12 Elite combines two types of cobalamin: adenosylcobalamin and methylcobalamin. These are “active” forms—meaning your body can make use of them right away.


Adenosylcobalamin helps preserve neuronal function

Leucine-Rich Repeat Kinase 2 (LRRK2) is a type of enzyme that modifies other proteins by adding phosphate groups.1 Inhibiting the activity of this enzyme has been associated with helping to preserve neuronal tissue.2

A series of preclinical studies has shown that the adenosylcobalamin form of B12 can inhibit the activity of multiple LRRK2 variants in neurons by decreasing phosphorylation (the addition of phosphate groups to amino acids).3

These studies found that adenosylcobalamin helped regulate healthy release of dopamine, a neurotransmitter that plays an important role in cognitive functions such as motor control, arousal, reinforcement and reward.3-6


A cofactor for energy metabolism

Adenosylcobalamin is active in the mitochondria, the powerhouses of your cells. It’s required as a cofactor for the synthesis of succinyl-CoA, a compound that supports cellular energy metabolism.7-9


Methylcobalamin for cellular health & beyond

Methylcobalamin is another neurologically active form of B12 (though in different ways than adenosylcobalamin). Methylcobalamin supports the central nervous system, and it’s essential for the replication and growth of cells.10

Methylcobalamin helps to maintain already healthy homocysteine levels.11-14 Inhibiting excess levels of this compound is key to maintaining healthy cardiovascular and neurological function.


B12 for a healthy brain and more

This B12 formula combines methylcobalamin and adenosylcobalamin to offer optimal cognitive support.

Supplement Facts

Serving Size 1 vegetarian lozenge

Servings Per Container 60

Amount Per Serving

Vitamin B12 (as adenosylcobalamin, methylcobalamin)

1000 mcg

Other ingredients: maltodextrin, xylitol, l-leucine, citric acid, guar gum, beet juice, modified food starch, stevia extract, strawberry flavor.

Dosage and Use

  • Dissolve one (1) lozenge daily under the tongue, or as recommended by a healthcare practitioner.


  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


Life Extension product references:

  1. Frontiers in neuroscience. 2020;14:527-527.
  2. The Neuroscientist. 2018;24(5):486-500.
  3. Cell Res. 2019;29(4):313-329.
  4. International archives of medicine. 2010;3:24-24.
  5. International Journal of Impotence Research. 2001;13(3):S18-S28.
  6. Elife. 2017;6
  7. EFSA Journal. 2008;6(10):815.
  8. Nutrients. 2013;5(12):5031-45.
  9. Nutrients. 2010;2(3):299-316.
  10. Lancet Neurol. 2006;5(11):949-60.
  11. Chem Biol Interact. 2006;163(1-2):94-112.
  12. N. I. o. Health. Riboflavin Fact Sheet for Health Professionals. Accessed
  13. Altern Med Rev. 2011;16(3):263-74.
  14. J Lipid Res. 2019;60(4):741-746.

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