Life Extension Mitochondrial Energy Optimizer with PQQ®, 120 capsules

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Known as "cellular dynamos," healthy mitochondria produce the energy that powers cells. As people age, however, mitochondria both lose function and decrease in number. Life Extension's unique Mitochondrial Energy Optimizer with PQQ was formulated to enhance mitochondrial function, protect delicate cellular structures, power-charge metabolic processes, and aid in the creation of new mitochondria.

Benefits at a Glance:

  • Supports healthy mitochondrial function and cellular energy output
  • Helps generate new mitochondria
  • Protects cellular structures against glycation reactions and free radicals
  • Inhibits inflammatory factors
  • Aids in cellular metabolism of glucose

Comprehensive Mitochondrial Support

As the importance of mitochondria for healthy cells comes into focus, researchers have identified a number of compounds that can help mitochondria function more efficiently and even help generate new mitochondria. These compounds have been combined into the innovative, multi-ingredient formula, Mitochondrial Energy Optimizer with PQQ.


The following unique ingredients in Mitochondrial Energy Optimizer with PQQ have all been shown to benefit mitochondria:

  • PQQ. This novel micronutrient represents a breakthrough in mitochondrial support. PQQ has been shown to actually trigger the creation of new mitochondria1 and protect the delicate structures of existing mitochondria.2-6
  • Carnosine. Carnosine has been shown to protect cellular structures against advanced glycation end-products (AGEs). These compounds are formed when proteins or lipids are cross-linked with sugars in a process known as glycation. Glycation is linked to a host of age-related events in the neurologic, vascular, renal and ocular areas.7-17 Carnosine protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.18-24
  • Luteolin. Luteolin is a plant-derived flavonoid that has been shown to inhibit inflammatory factors, which have been linked to virtually every undesirable consequence of aging. Luteolin works by inhibiting pro-inflammatory cytokines, including interleukin-1 and tumor necrosis factor-alpha.25-34
  • Benfotiamine. Benfotiamine operates along multiple pathways to protect cellular integrity. It has been shown in studies to protect cells against the effects of excess glucose by increasing glucose metabolism and protecting against the formation of AGEs.35-43 Studies have shown that the ideal fasting glucose levels are between 70–85 mg/dL. Many aging people, however, have fasting glucose levels above 90 mg/dL. Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels already within normal range. Additionally, benfotiamine has been shown to act as an antioxidant that supports healthy DNA function.44
  • Pyridoxal 5'-Phosphate. This active form of vitamin B6 has been shown to protect against glycation reactions caused by both lipids and proteins.45-49
  • R-lipoic acid. R-lipoic acid protects mitochondria against free radicals while promoting youthful mitochondrial function. The R-lipoic form is more potent than the other form of lipoic acid on the supplement market.50-57
  • Taurine. This amino acid supports neurite growth58 and powerfully protects the mitochondria59 from oxidative damage to enhance energy production within cells.58,60,61  Taurine is prevalent throughout the body62 and found in especially high amounts in the metabolically active cells that require high mitochondrial energy production (brain,62 nerve, eye cells,63 heart,64 and skeletal muscle65).

Purchasing each of these potent ingredients individually would be prohibitively expensive. But Mitochondrial Energy Optimizer with PQQ combines them into one cost-effective formulation that helps support healthy mitochondria.

Supplement Facts

Serving Size 4 capsules

Servings Per Container 30

Amount Per Serving

Vitamin B6 (as pyridoxal 5’-phosphate)

100 mg


18 mg


1000 mg


800 mg


150 mg

R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate)

150 mg

PQQ (Pyrroloquinoline quinone) disodium salt

10 mg

Luteolin [from orange extract (fruit)]

8 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, stearic acid, silica, hydroxypropyl cellulose, candelilla wax, beeswax, calcium silicate.


Bio-Enhanced® is a registered trademark of Geronova Research, Inc.

Dosage and Use
  • Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


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