Age Spot & Skin Brightening Serum is formulated with a unique blend of natural ingredients that helps to brighten the skin and reduces the appearance of:
- Age Spots
- Dark Spots
- Uneven Skin Tone
The ingredients in this product also help to protect the skin against ultraviolet (UV) rays damage from sun exposure.
In a human study conducted in 2018, up to 86% of volunteers saw a significant reduction in UV spot counts after 7 days.1 After 28 days, there was significant reductions:
- in number of spots – 14% reduction in 65% of subjects
- in uneven tone – 24% reduction in 70% of subjects1
HOW DOES PIGMENTATION HAPPEN?
Melanin is the pigment that gives human skin, hair, and eyes their colors to protect against the damaging effects of UV rays.
It is produced by specialized skin cells, known as melanocytes, through complex enzymatic processes:
- Firstly, UV exposure and free radicals damage the DNA of skin cells.
- The DNA damage of skin cells stimulated the binding of alpha-Melanocyte-stimulating hormone (α-MSH) to its receptors on melanocytes.
- Then, the binding increases melanin production in melanocytes by converting amino acid tyrosine to melanin with the help of the enzyme tyrosinase.
UV exposure, hormonal changes, genetic factor and aging can lead to over-production of melanin, causing hyperpigmentation, seen as age spots, dark or brown spots and uneven skin tone.
HOW DOES THE INGREDIENTS OF AGE SPOT & SKIN BRIGHTENING SERUM HELP TO PREVENT HYPERPIGMENTATION?
Berries Complex – Consisting of black mulberry, white mulberry, blueberry and bearberry extracts providing Mulberrosides, Polyphenols and Arbutin. These compounds have potent antioxidative properties to reduce oxidative stress induced by UV rays and helps to brighten the skin. They also help to inhibit tyrosinase and stop the enzymatic processes needed to form melanin.2-5
Swiss Garden Cress Sprouts (as SulforaWhite 2%) – Is rich in sulforaphane which inhibits the binding of α-MSH to its receptors to trigger skin pigmentation. Sulforaphane also neutralizes free radicals to keep the skin fair.4-7
Niacinamide – Providing high purity Niacinamide (vitamin B3) to fight against UV damage and helps to balance uneven skin tone, thus diminishing dullness.4,5,8
Royal Epigen P5 – Inspired by epigenetic science, this revolutionary ingredient is based on a biologically active peptide that mimics the anti-aging function of Royalactin in royal jelly. The peptide is formulated in a soft sphere carrier system to ensure bioavailability and the best skin regeneration results.9 It accelerates epidermal regeneration to smoothen skin and activate the cellular cleaning process to reveal a more evenly toned skin.9
Hyaluronic Acid – Moisturizes the skin and helps to maintain a fresh and healthy appearance.10-16
Aqua (Water), Ethylhexyl Methoxycinnamate, Isohexadecane, Pentaylene Glycol, Squalane, Butylene Glycol, Caprylic/Capric Triglyceride, Niacinamide, Ethylhexyl Triazone, Isopropyl Palmitate, Steareth-21, Glycerin, Lepidium Sativum Sprout Extract, Coco-Caprylate, Butyl Methoxydibenzoylmethane, PEG-8 Distearate, Steareth-2, Phenoxyethanol, Titanium Dioxide, Tocopheryl Acetate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Panthenol, Butyspermum Parkii (Shea) Butter, Allantoin, Parfum (Fragrance), Carbomer, Ethyl-hexylglycerin, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Hydrogenated Lecithin, Lecithin, Phenethyl Alcohol, Polysorbate 60, Sodium Hyaluronate, Morus Alba Fruit Extract, BHT, Citric Acid, Arctostaphylos Uva Ursi Leaf Extract, Morus Nigra Leaf Extract, Vaccinium Myrtillus Leaf Extract, Tocopherol, Matodextrin, Pentapeptide-48.
Paraben-free / Silicon free.
Suitable for all skin types. Apply in the morning and evening onto thoroughly cleansed face and neck.
Keep tube tightly capped. Store in a cool and dry place, away from direct sunlight.
Product of Switzerland
- Carried out by an independent lab on behalf of Swissforce Pharma AG. 2018. Efficacy evaluation of Age Spot & Skin Brightening Serum 18E1457.
- Burlando B, Clericuzio M, Cornara L. 2017. Moraceae plants with tyrosinase inhibitory activity: A review. Mini Rev Med Chem;17:108–121.
- Freistas MM et al. 2016. Extracts of Morus nigra L. leaves standardized in chlorogenic acid, rutin and isoquercitrin: tyrosinase inhibition and cytotoxicity. PLoS ONE 11: 1-24.
- Hollinger JC, Angra K and Halder RM. 2018. Are natural ingredients effective in the management of hyperpigmentation? A systematic review. J Clin Aesthet Dermatol. 11:28–37.
- Zhu, W; Gao, J. 2008. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders. J. Investig. Dermatol. Symp. Proc 13, 20–24.
- Shirasugi, I.; Kamada, M.; Matsui, T.; Sakakibara, Y.; Liu, M.C.; Suiko, M. 2010. Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells. Biosci. Biotechnol. Biochem 74, 579–582.
- SulforaWhite: Garden Cress Sprout Fraction with Strong Whitening Activity. Dr. Daniel Schmid, Mibelle Biochemistry, Switzerland.
- J. Wohlrab, D. Kreft. 2014. Niacinamide - Mechanisms of action and its topical use in dermatology. Skin Pharmacol Physiol, 27 (6) pp. 311-315.
- Esther Belser. 2017. Epigenetics – A New Way to Rejuvenate Skin. Euro Cosmetics. 5:16-20.
- Masson F. [Skin hydration and hyaluronic acid]. Ann Dermatol Venereol. 2010;137 Suppl 1:S23-5.
- McKee CM, Penno MB, Cowman M, et al. (1996). Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest. 98(10):2403-13.
- Beasley KL, Weiss MA, Weiss RA. Hyaluronic acid fillers: a comprehensive review. Facial Plast Surg. 2009;25(2):86-94.
- Teriete P, Banerji S, Noble M, et al. (2004). Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol Cell. 13(4):483-96.
- Wang Y, Lauer ME, Anand S, et al. (2014). Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress. J Biol Chem. 289(46):32253-65.
- Jiang D, Liang J, Noble PW. (2007). Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol. 23:435-61.
- Hasova M, Crhak T, Safrankova B, et al. (2011). Hyaluronan minimizes effects of UV irradiation on human keratinocytes. Arch Dermatol Res. 303(4):277-84.