Life Extension Endothelial Defense™ Pomegranate Plus, 60 softgels

There is a thin layer of cells that line the insides of your blood vessels. It is called the vascular endothelium, and it’s absolutely essential to your cardiovascular health. This cellular layer is so important, we created a formula that focuses exclusively on providing it with focused nutritional support: Endothelial Defense™ Pomegranate Plus.

Protecting the endothelial cells that line your blood vessels is critical for maintaining lasting cardiovascular health.

Endothelial Defense™ Pomegranate Plus Benefits

• Supports endothelial cell health and function with pomegranate seed, flower and fruit extract
• Helps maintain blood vessel and circulatory health with Cardiose® sweet orange peel extract
• Encourages natural antioxidant production with new Extramel® melon pulp concentrate

The endothelial layer of your blood vessels plays an important role in regulating the health of your cardiovascular system—and with it, things like blood pressure, circulatory health and more. As you age, protecting the endothelium is critical for maintaining overall health—and Endothelial Defense™ Pomegranate Plus combines three nutrients that do just that.

Pomegranate seed, fruit and flower extracts

Pomegranate is a potent source of polyphenol extracts. These polyphenol compounds have valuable health benefits, including promoting healthy endothelial function, inhibiting oxidative stress, supporting metabolic and cardiovascular health and promoting a healthy inflammatory response.^1-11 Endothelial Defense Pomegranate Plus contains standardized extracts from pomegranate flower and fruit, as well as extract of pomegranate seed oil.

Melon concentrate promotes antioxidant production

Extramel® is a concentrate of a special variety of a French melon. It encourages the body to produce superoxide dismutase (SOD), a potent inhibitor of oxidative stress.^12,13 In pre-clinical models, consuming Extramel® melon concentrate increased SOD levels in various organ tissues.¹⁴

Extramel® appears to support overall quality of life as well. In not one, but two studies, subjects consuming 10 mg a day of this melon concentrate reported decreased feelings of general fatigue. Healthy stress response and increased feelings of well-being were reported as well.^15,16

Clinically-studied compound from sweet orange peels

There is a compound derived from citrus peels called hesperetin. Hesperetin has been found to promote endothelial production of nitric oxide, which encourages vasodilation—a key requirements for healthy circulation. Cardiose® sweet orange peel extract is standardized to be 90% hesperetin-7-O-rutinoside 2S, an easily absorbed kind of hesperetin.¹⁷

In a randomized controlled trial, 500 mg of sweet orange peel extract produced a 20% improvement in flow-mediated dilation, an indicator of healthy endothelial function. This extract also promoted a healthy inflammatory response.¹⁸