5 Health Benefits of Chlorophyllin

5 Health Benefits of Chlorophyllin

5 Health Benefits of Chlorophyllin

Chlorophyll is the pigment synthesized with the use of sunlight by plants, and which gives them their green color. Anytime you eat green vegetables, you're consuming chlorophyll.

A similar compound, chlorophyllin is a water-soluble derivative of chlorophyll that is often included in nutritional supplements due to its greater stability in comparison with naturally occurring chlorophyll.

A review published in 2015 noted, "Chlorophyllin has been shown to exhibit potent antigenotoxic, anti-oxidant, and anticancer effects."1

Let’s explore the [green] magic of chlorophyllin.


Chlorophyllin Targets Toxins

Preventing genetic mutations caused by various toxins is one of chlorophyll's as well as chlorophyllin's best-known functions, aside from their essentiality to the plant kingdom.2 Both chlorophyll and chlorophyllin form complexes with certain types of mutagens to block their activity.3

A mutagen is an agent, such as radiation or a chemical substance, that causes mutations in the DNA.

Some of the earliest published research evaluating the effects of chlorophyllin involved tests of mixtures of different potential mutagens in a strain of Salmonella bacteria. The research found that chlorophyllin inhibited 90% to 100% of the mutagenicity of eight out of ten mixtures of extracts that included fried beef, cigarette smoke, chewing tobacco, airborne particles, coal dust, and diesel emission particles4.

In human white blood cells known as lymphocytes, chlorophyllin inhibited free radicals and protected DNA from damage induced by two mycotoxins produced by fungal food contaminants.5

Chlorophyllin has also been demonstrated to reduce biomarkers of the mycotoxin aflatoxin B(1) produced by Aspergillus mold. This toxin increases the risk of liver cancer in chronically exposed individuals.6 In human volunteers, chlorophyll as well as chlorophyllin limited ingested aflatoxin bioavailability .7


Chlorophyllin Protects Against Radiation

Chlorophyllin has also been shown to help prevent genetic damage caused by radiation.8

One study found that chlorophyllin was better able to protect against radiation in rat mitochondria than vitamin C and glutathione.9


Chlorophyllin Plays a Role in Cancer

In addition to cancer prevention, chlorophyllin could also play a role in the treatment of the disease. Research in a rodent model of forestomach carcinoma found that chlorophyllin inhibited the disease's development by decreasing transforming growth factor beta (TGFb) signaling, thereby blocking cell proliferation, angiogenesis (the formation of new blood vessels), invasion, and metastasis.10

Research involving a hamster model of cheek pouch carcinoma found an inhibition of angiogenesis associated with chlorophyllin supplementation that led the researchers to conclude that the compound is an attractive candidate for preventing tumor progression.11 Other research involving this model found an alteration of gene expression that was reversed by chlorophyllin.12

In human pancreatic cancer cell lines, chlorophyllin dose-dependently decreased proliferation while diminishing the generation of mitochondrial reactive oxygen species.13

In breast cancer cells, chlorophyllin was found to inhibit cell proliferation by deactivating extracellular signal-regulated kinases, a subfamily of mitogen-activated protein kinases involved in cell survival, proliferation, and differentiation.14


Chlorophyllin Fights Infections

Chlorophyllin also appears to act against certain microorganisms, including influenza
and human immunodeficiency virus (HIV).15 

Investigation of chlorophyllin's mechanisms against Propionibacterium acnes, the bacterial culprit in acne, found a reduction in growth of the bacterium and a decrease in its inflammatory chemokine production.16


Chlorophyllin Neutralizes Odor

Interestingly, chlorophyllin and chlorophyll have been the subject of research over the past several decades concerning their ability to neutralize body odors! The compounds have been investigated for the control of urinary odor in catheterized patients and for the prevention of mouth odor,17 perspiration, intestinal gas, and fecal odor.18

If your intake of green vegetables is less than optimal, chlorophyllin supplementation is a convenient option with plenty of research to support it. Protect your DNA from the numerous threats encountered in our food supply and environment with the magic of green chlorophyll or chlorophyllin.